C54142: Photoprotection part 2 - investigating oxidative stress

Working from the premise that blue-violet light induces apoptotic death in RPE cells, researchers (including our team) took a step towards fine tuning our understanding of the link between blue light and age-related macular degeneration via the accumulation of oxidative stress and the modulation of cell defence mechanisms. The first article discussed the processes at a molecular level, and in this article we will discuss in more detail the results of research looking at the outcome of short wavelength light irradiation.

To identify the role of blue-violet light in accelerating ageing of the outer retina, and more specifically to understand the early stages in this process, researchers used their cell and light models¹ to address two key questions;