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Coats' disease is a developmental, non-inherited, progressive and almost invariably unilateral retinal vascular disease. There is a variable pattern of retinal telangiectasia, with focal dilatation of retinal vessels that are incompetent and leak fluid. Exudative retinal detachment is the most significant among multiple possible complications of this condition.
Central vision may also be impaired when retinal edema and exudates affect the macula. Coats' disease is one of the causes of leukocoria (a white pupillary reflex) in children, of which retinoblastoma is the most important diagnosis requiring exclusion.
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