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The earliest defects in glaucoma are probably small focal paracentral scotomas or depressions in sensitivity close to fixation. These are frequently seen initially in the superior nasal area and may mirror changes observed with the ophthalmoscope, such as erosion of the inferior temporal neuroretinal rim of the optic disc and retinal nerve fibre layer defects. Some authorities suggest that a generalised diffuse loss is also a potential early change. It has to be remembered, however, that these patients are often elderly with lenticular opacities and smaller pupils, changes that can lead to a similar loss of sensitivity. The least common defect is the so-called temporal wedge corresponding to damage at the nasal neuroretinal rim.
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