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PIOL is usually a diffuse large B-cell non-Hodgkin's lymphoma. It typically affects immunocompetent persons over age 50, or younger immunocompromised individuals. Historically, the diagnosis has often been reached after a presumptive case of uveitis has failed to respond completely to steroid therapy ('uveitis masquerade syndrome'). PIOL is usually bilateral.
Symptoms
The most common symptoms are blurred vision and floaters. Other potential symptoms include photophobia, ocular pain and a red eye. Other neurological or systemic symptoms (for example, motor or sensory deficits, altered cognition, seizures, fevers or weight loss) suggest more extensive disease.
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