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Retinoschisis is a splitting within the sensory retina, and may occur in age-related degenerative and X-linked recessive forms (see next week: Retinoschisis - Juvenile X-Linked). Degenerative retinoschisis is an acquired condition involving a splitting of the sensory retina, usually within the plexiform layers, creating a large 'cyst'.
Degenerative retinoschisis initially occurs in the far retinal periphery, beginning with an area of microcystoid degeneration, a degenerative change adjacent to the ora serrata that is common to all adult eyes. A secondary retinoschisis may present in other ocular diseases such as diabetic retinopathy and retinopathy of prematurity.
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