In vitro studies also suggest that the performance of silicone hydrogel contact lenses may decline over time,4,5 but clinical studies are needed to confirm this hypothesis.
A study, recently conducted in the US, was designed to test two silicone hydrogel contact lenses with different replacement intervals and compare their performance, as well as to determine how each lens' performance changes over the manufacturer's recommended life of the lens.
Leading silicone hydrogel lenses studied
In a multicentre, subject-masked study, 18- to 45-year-old successful spherical soft contact lens wearers were randomised to wear either a senofilcon A lens with a recommended replacement interval of two weeks (Acuvue Oasys with Hydraclear Plus, Johnson & Johnson Vision Care) or a lotrafilcon B lens with a recommended replacement interval of one month (Air Optix Aqua, Alcon). All subjects signed written informed consent forms, and the study received Institutional Review Board (IRB) approval and was registered on www.clinicaltrials.gov.6
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