A link between proteins associated with Alzheimer’s disease and age-related macular degeneration (AMD) has been identified in new research.
Researchers said the findings, which were published in Cells, could lead to new treatments, with a reduced need to use animals in future research.
Donor eyes from patients who had AMD have previously been shown to contain high levels of amyloid beta proteins, a primary driver of Alzheimer’s disease.
By exposing retinal pigment epithelium (RPE) cells of mouse eyes, researchers were able to look at the effect of amyloid beta on living eye tissue, using non-invasive imaging techniques.
It revealed that mouse eyes developed retinal pathology that was 'strikingly similar' to AMD in humans, researchers explained.
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