Keratoconus study identifies DNA variations

An international team of researchers have detected DNA variations that could provide clues as to how keratoconus develops in a genetic study.

The study, published in Communications Biology, compared the full genetic code of 4,669 people with keratoconus to that of 116,547 people who do not have the condition.

Professor Alison Hardcastle, study lead, said: ‘This study represents a substantial advance of our understanding of keratoconus. We can now use this new knowledge as the basis for developing a genetic test to identify individuals at risk of keratoconus, at a stage when vision can be preserved, and in the future develop more effective treatments.’