Vessel study

The exact nature of the VEGF molecule involved in vessel proliferation is being established.

Researchers at University College London, headed by Professor David Shima, have identified a variant of the vascular endothelial growth factor (VEGF) which triggers new vessel growth.

According to Shima, the so-called VEGF-164 molecule 'drives not only ocular neovascularisation and vascular permeability, but also an undesirable inflammatory reaction.' It is this inflammatory function that may present a target for treatment.

Speaking at this week's European Meeting on Vascular Biology, Shima also warned that effective elimination of the VEGF 164 activity would stop neovascularisation but would also impact on the beneficial effect of the substance on protecting nerve tissue.