Choroidal neovascularisation (CNV) refers to the growth of new blood vessels from the choroid, through breaks in Bruch's membrane, to under either the retinal pigment epithelium (RPE, type 1) or the sensory retina (type 2) or both. The condition has potentially devastating visual consequences. The etiology of CNV appears to be related to damage to the RPE and Bruch's membrane, in the presence of retinal hypoxia. The RPE serves as a key part of the blood-retinal barrier, and a breach may allow angiogenic factors to act on the choroidal vasculature.
ASSOCIATED CONDITIONS
Degenerative conditions - age-related macular degeneration, myopia, angioid streaks. These are among the more common conditions associated with CNV
Inflammatory or infectious conditions - sarcoidosis, histoplasmosis, acute posterior multifocal placoid pigment epitheliopathy, birdshot chorioretinitis, serpiginous choroiditis, toxoplasmosis
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