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Sickle-cell disease (SCD) is a genetically determined haemoglobinopathy. Haemoglobin is a key protein of the erythrocyte, responsible for oxygen transport in the blood. SCD causes erythrocyte dysfunction with reduced blood flow, increased blood clots, tissue hypoxia and eventual pathology.
Erythrocytes have a shortened life, which in some conditions may cause haemolytic anaemia. All parts of the body, including the eye, may be affected by vascular complications. Proliferative retinopathy and sequelae are a risk in the eye.
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