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Advanced Image Interpretation part 2 case 1 page 5

Clinical Practice
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Fundus autofluorescence (FAF) imaging (Blue Peak) allows assessment of the integrity and metabolic activity within the RPE layer. Angioid streaks are a defect in Bruch’s membrane, these often appear as hypo-autofluorescent fissures (upper figure).  Angioid streaks are often associated with retinal pigment epithelial atrophy (lower figure, red) which is preceded by hyper fluorescent patches (lower figure, green).  Extension of the streaks towards the fovea has a poor prognosis.

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